Ankylosing Spondalysis (AS) is an inflammatory arthritis affecting the spine and large joints. Ankylose means becoming stiffened or united. It mainly affects the axial skeleton. Due to that, joint margins gradually ossify. because of the prevalence of HLA-B27 (not a confirmatory test for AS) and/or TNF- and specific bacterial agent Klebsiella, which has an established relationship with HLA-B27 It develops in late adolescence or early adulthood. Symptoms are Low back pain, tenderness, or stiffness. • Worse at night or in the morning, but improved by activity or exercise • Muscle spasms and exhaustion • Limited spinal mobility and chest expansion. • Uveitis, which is an inflammation of the uvea (the layer between the retina and the cornea). • The appearance of 'Bamboo Spine.'